منابع مشابه
LXR antagonists induce ABCD2 expression.
X-linked adrenoleukodystrophy (X-ALD) is a rare neurodegenerative disorder characterized by the accumulation of very-long-chain fatty acids resulting from a beta-oxidation defect. Oxidative stress and inflammation are also key components of the pathogenesis. X-ALD is caused by mutations in the ABCDI gene, which encodes for a peroxisomal half ABC transporter predicted to participate in the entry...
متن کاملLiver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression. Novel cross-talk in gene regulation.
The peroxisomal ATP binding cassette (ABC) transporter adrenoleukodystrophy-related protein, encoded by ABCD2, displays functional redundancy with the X-linked adrenoleukodystrophy-associated protein, making ABCD2 up-regulation of therapeutic value. Cholesterol lowering activates human ABCD2 in cultured cells. To investigate in vivo regulation by sterols, we first characterized a sterol regulat...
متن کاملCan Novel AMPA and NMDA Receptor Antagonists Induce Analgesia?
The glutamate receptors in the nervous system are related to nociceptive response. These receptors include the AMPA (a -amino-3-hydroxy-5-methyl-4isoxazolepropionate) receptor and the NMDA (N-methyl-D-aspartate) receptor1). The purpose of this study was to investigate whether novel antagonists of these glutamate receptors could inhibit the nociceptive response in the spinal cord of male Wistar ...
متن کاملLXR-agonists regulate ApoM expression differentially in liver and intestine.
Apolipoprotein M (apoM) has been suggested to play a role in reverse cholesterol transport. Here we studied the influence of liver X-receptor (LXR) agonist on the transcriptional regulation of apoM. Studies were performed in murine liver and intestinal mucosal cells in vivo and in human intestinal Caco-2 cells in vitro. The expression of apoM was analyzed by quantitative real time PCR, and comp...
متن کاملIAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis
James E. Vince,1 W. Wei-Lynn Wong,1,8 Nufail Khan,1,8 Rebecca Feltham,1,8 Diep Chau,1 Afsar U. Ahmed,1 Christopher A. Benetatos,2 Srinivas K. Chunduru,2 Stephen M. Condon,2 Mark McKinlay,2 Robert Brink,3 Martin Leverkus,4 Vinay Tergaonkar,5 Pascal Schneider,6 Bernard A. Callus,1 Frank Koentgen,7 David L. Vaux,1 and John Silke1,* 1Department of Biochemistry, La Trobe University, Kingsbury Drive,...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
سال: 2014
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2013.11.003